Live Webinar : Simple Western: Strengthening Dose-Response Relationships in Drug Development
October 27, 2021, 8:00 AM
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Speaker: Chris Heger, Ph.D. Director, Applications Science Analytical Solutions Division, Bio-Techne

Selecting the appropriate drug concentration and frequency requires careful study of the relationship between a drug’s dose and the intended effect. From a simplistic view, it’s like what Goldilocks discovered in the cabin: if you don’t receive enough drug there’s little to no effect and if too much drug is given, the patient may experience toxicity or worse. Careful dose-response studies to understand the pharmacokinetics and pharmacodynamics of a compound are a critical step of drug development and rely on quantitative protein analysis techniques that provide accurate measures of protein abundance following varying dose of a drug. Simple Western is an ideal platform for dose-response measurements in drug development studies, with high throughput, speed, sensitivity, and accuracy. Simple Western can cut through the noise associated with matrix effects commonly seen with ELISAs, but also dissect out key changes in not only target abundance, but also target degradation or post-translational modifications. Together, this can afford researchers a deeper, and more accurate understanding of how their compound affects the target. In this webinar, you will learn how Simple Western Charge and Size assays can be leveraged for accurate dose response measurements in a variety of applications including pharmacokinetic assays and targeted protein degradation (TPD).

Live Webinar: Use of automated immunoblotting for characterization of SARS-CoV-2 antibody responses in COVID-19 patients
November 18, 2021, 8:00 AM PST
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Speaker: Dr. Javier Castillo-Olivares, DVM, MSc, PhD, MRCVS, Univ. of Cambridge

Speaker: Dr. Matteo Ferrari, DIOSynVax, Department of Veterinary Medicine, Cambridge, United Kingdom

In this seminar Dr. Castillo-Olivares and Dr. Matteo Ferrari will present the data they have generated using the ProteinSimple Jess technology to characterize the antibody responses of SARS-CoV-2 infected individuals. The results show IgG, IgA and IgM reactivities of sera from patients against the main SAR-CoV-2 antigens (N, whole Spike and their sub-units S1, S2 and RBD). They will discuss these results in the context of other serological data obtained with other assays.

Live Webinar: Accelerate Your Biologic Therapeutic Development with a USP 129-Suitable Automated CE-SDS Platform
December 1, 2021, 8:00 AM PST
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Dr. Richard Easton, Technical Director of Structural Analysis at BioPharmaSpec, discusses the use of the automated Maurice™ platform to provide capillary electrophoresis-sodium dodecyl sulfate (CE-SDS) data for biosimilar comparability studies and Dr. Chris Heger, Director of Applications Science, Bio-Teche, will discuss characterization of Maurice CE-SDS PLUS for USP <129>suitability.

What you'll learn in this webinar:
- Crucial insights into the structure of mAbs, heavily glycosylated species, and PEGylated species
- Information on size heterogeneity, partial species in mAbs, and other impurities
- Reproducible batch-to-batch comparisons
- A USP <129> suitable CE-SDS method for comparable data, less fragmentation, and low injection-induced variations.